منابع مشابه
Tuberculosis and trimethoprim-sulfamethoxazole.
The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunoco...
متن کاملSingle dose pharmacokinetics of trimethoprim.
Single oral dose trimethoprim pharmacokinetics were determined in 18 children aged 3 months to 13 years. Trimethoprim suspension was rapidly absorbed and quickly and widely distributed. The mean clearance was considerably faster and the elimination half life considerably shorter than values reported in adults. Only one third of the administered drug dose was recovered from the urine within 24 h...
متن کاملResistance to trimethoprim and sulfonamides.
Sulfonamides and trimethoprim have been used for many decades as efficient and inexpensive antibacterial agents for animals and man. Resistance to both has, however, spread extensively and rapidly. This is mainly due to the horizontal spread of resistance genes, expressing drug-insensitive variants of the target enzymes dihydropteroate synthase and dihydrofolate reductase, for sulfonamide and t...
متن کاملConsiderations when prescribing trimethoprim-sulfamethoxazole.
famethoxazole remains a popular antibiotic because of its low cost, effectiveness and familiarity among clinicians. It is the most frequently prescribed antibiotic for urinary tract infections in Canada. Other indications include treatment of infections caused by Pneumocystis jiroveci, Toxoplasma gondii, Stenotrophomonas maltophilia and community-associated methicillin-resistant Staphylococcus ...
متن کاملHypersensitivity pneumonitis induced by trimethoprim.
intracranial course. The sixth nerve occupies a superficial position in relation to the fourth ventricle, which communicates directly through the foramina of Magendie and Luschka with the subarachnoid space. Dye studies have shown that agents introduced into the spinal canal frequently reach the medulla, which may explain the peculiar affinity of the sixth nerve to palsy.4 The contrast agents i...
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ژورنال
عنوان ژورنال: BMJ
سال: 1968
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5604.557-b